ethyl cysteinate
L-Cysteine ethyl ester hydrochloride
CAS: 868-59-7
Molecular Formula: C5H12ClNO2S
ethyl cysteinate - Names and Identifiers
ethyl cysteinate - Physico-chemical Properties
| Molecular Formula | C5H12ClNO2S |
| Molar Mass | 185.67 |
| Melting Point | 123-125°C(lit.) |
| Boling Point | 205.9°C at 760 mmHg |
| Specific Rotation(α) | -13 º (c=8, 1 N HCL) |
| Flash Point | 78.3°C |
| Water Solubility | Soluble in water. |
| Vapor Presure | 0.244mmHg at 25°C |
| Appearance | White powder |
| Color | white |
| BRN | 3562600 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Hygroscopic |
| Refractive Index | -11.5 ° (C=8, 1mol/L |
| MDL | MFCD00012631 |
| Use | Used for biochemical reagents, pharmaceutical intermediates. |
ethyl cysteinate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | HA1820000 |
| TSCA | Yes |
| HS Code | 29309090 |
ethyl cysteinate - Nature
Open Data Verified Data
- This product is white or colorless crystal, with special odor and acid. Melting point 17 5~180 °c. Soluble in water, very slightly soluble in ethanol. 3% aqueous solution pH 1.2. Soluble in ammonia and acetic acid, insoluble in most organic solvents. It is reductive, can prevent non-enzymatic browning and antioxidant effect. Cysteine acid stability, and in neutral and alkaline solution is easy to air oxidation of cystine, trace iron and heavy metals can promote its oxidation. Its hydrochloride is more stable, so it is generally made into hydrochloride.
- L-cysteine is a sulfur-containing amino acid and is a "non-essential" amino acid. In the living body, the sulfur atom of methionine is substituted with the hydroxyl oxygen atom of serine and then synthesized via cystathionine. Starting from L-cysteine, glutathione can be produced. It is involved in the reduction process of cells and the metabolism of phospholipids in the liver, which can protect liver cells from damage and promote liver function. At the same time can stimulate hematopoietic function, increase white blood cells and promote the recovery of skin damage.
Last Update：2024-01-02 23:10:35
ethyl cysteinate - Preparation Method
Open Data Verified Data
- extraction, electrolysis method by human hair (or pig hair) hydrolysis, purification, purification, electrolytic reduction, and then through filtration, concentration, crystallization, drying, can be finished. Of hydrochloric acid at 10 mol/L was added to the hydrolysis tank, heated to 70-80 °c, rapidly poured into 100 of human hair or pig hair, and the heating was continued to °c at 1-1 °c. Within 5h, the temperature was raised to 110 N117 ℃, and hydrolysis was performed. 5~7H (from 100 C), cooling. It was then discharged and filtered. The filtrate was added with 30% to 40% industrial sodium hydroxide solution under stirring when the pH reached 3. After 0, the lye was added rapidly until the pH value was 4.8, and the mixture was left to stand for 36H. The precipitate was separated and then centrifuged and dried to obtain the crude cystine. Weigh 15 0kg of cystine, add 90kg of 10 mol/L hydrochloric acid and 360kg of water, heat to 65 -70 ℃, and stir the solution 0. 5h, then add activated carbon 12kg, heating to 80~85 degrees Celsius, heat preservation 0. 5h, Plate and Frame pressure filtration. The filtrate was heated to 80-85 °c, and 30% sodium hydroxide was added with stirring until the pH was stopped at 4.8. Let it stand, precipitate the crystals, siphon the supernatant (cystine and tyrosine can be recovered), separate the bottom of the precipitate and then spin dry, and then enter the second decolorization process. Weigh the crude cystine (lOOkg), add 1 mol/L hydrochloric acid (500L), heat to 70 ° C., and add activated carbon (3-5kg). The temperature was raised to 85 ° C., the temperature was maintained and stirred for 0. 5H, and the plate and frame were pressure filtered. About 1.5-fold distilled water was added to the filtrate, heated to 75-85 ° C., and neutralized with 12% aqueous ammonia under stirring to pH -4.0, at which point cystine crystallized out. The crystal was centrifuged and dried, washed with distilled water until no chloride ion was found, and dried under vacuum at 60-70 ℃ to obtain cystine fine product. Cystine, distilled water and hydrochloric acid were added to the electrolytic cell for stirring and dissolution, and the electrolysis was controlled below 50 ° C. To the end point. The resulting electrolyte was saturated with H2S. Filtering to remove residue, filtrate and then decolorizing with activated carbon, filtering to remove carbon residue, filtrate decompression concentration, concentrated liquid cooling crystallization, centrifugal separation, drying, L-cysteine hydrochloride can be obtained.
- enzymatic method
Last Update：2022-01-01 11:09:57
ethyl cysteinate - Use
Open Data Verified Data
- for the treatment of radioactive drug poisoning, heavy metal poisoning, toxic hepatitis, serum sickness, etc., and can prevent liver necrosis. Its usage and dosage: intramuscular injection, 100 ~ 200mg each time, 1~2 times a day.
- used in cosmetics for the perm fine, sunscreen, hair growth perfume, hair care fine.
- as a food additive, used in bread to promote the formation of gluten and promote fermentation, mold, prevent oxidation. For natural fruit juice, to prevent oxidation and color change of vitamin C.
Last Update：2022-01-01 11:09:57
ethyl cysteinate - Safety
Open Data Verified Data
light-shielding, closed, stored in a cool and dry place.
Last Update：2022-01-01 11:09:57
ethyl cysteinate - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | L-cysteine ethyl ester hydrochloride is an amino acid derivative useful as an intermediate in the synthesis of pharmaceuticals. |
| synthesis method | synthesis of L-cysteine ethyl ester hydrochloride: L-cysteine (24.20g,0.20mol) 300mL of ethanol was placed in a 500mL eggplant bottle, and sulfoxide chloride (22mL,0.30mol) was slowly added dropwise under the condition of ice water bath. After the dropwise addition was completed, the reaction was continued for 3H at room temperature, and the reaction was heated to reflux for 12h. The reaction solution was cooled to room temperature, and the solvent was distilled off to obtain 36.42g of white powder, yield 98.1%. |
| Use | for biochemical reagents, pharmaceutical intermediates. |
Last Update：2024-04-09 20:52:54
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